Teruhisa Tokunaga Selected Research

SMP-534

6/2009	The anti-fibrotic agent SMP-534 attenuates bleomycin-induced pulmonary fibrosis in hamsters.
1/2008	Chronic administration of SMP-534 ameliorates renal dysfunction in 5/6 nephrectomized rats.
1/2007	Amelioration of established diabetic nephropathy by combined treatment with SMP-534 (antifibrotic agent) and losartan in db/db mice.
4/2006	SMP-534 ameliorates progression of glomerular fibrosis and urinary albumin in diabetic db/db mice.
1/2006	Enhanced effect of combined treatment with SMP-534 (antifibrotic agent) and losartan in diabetic nephropathy.
11/2005	SMP-534 inhibits TGF-beta-induced ECM production in fibroblast cells and reduces mesangial matrix accumulation in experimental glomerulonephritis.

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Teruhisa Tokunaga Research Topics

Disease

5	Fibrosis (Cirrhosis) 06/2009 - 11/2005
3	Diabetic Nephropathies (Diabetic Nephropathy) 01/2007 - 01/2006
2	Renal Insufficiency (Renal Failure) 01/2008 - 04/2006
2	Nephritis 04/2006 - 11/2005
1	Body Weight (Weight, Body) 06/2009
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 06/2009
1	Hypertension (High Blood Pressure) 01/2008
1	Type 2 Diabetes Mellitus (MODY) 04/2006
1	Glomerulonephritis 11/2005

Drug/Important Bio-Agent (IBA)

6	SMP-534IBA 06/2009 - 11/2005
3	Transforming Growth Factor beta (TGF-beta)IBA 04/2006 - 11/2005
2	Losartan (Cozaar)FDA LinkGeneric 01/2007 - 01/2006
2	AlbuminsIBA 04/2006 - 01/2006
1	indium-bleomycinIBA 06/2009
1	Bleomycin (Blenoxane)FDA LinkGeneric 06/2009
1	salicylhydroxamic acid (SHAM)IBA 01/2008
1	Antihypertensive Agents (Antihypertensives)IBA 01/2007
1	Insulin (Novolin)FDA Link 04/2006
1	Antifibrotic AgentsIBA 04/2006
1	benzamideIBA 04/2006
1	Angiotensin IIIBA 01/2006
1	Hydroxyproline (4 Hydroxyproline)IBA 11/2005
1	anti-Thy antibodyIBA 11/2005

Therapy/Procedure

1	Therapeutics 01/2006
1	Oral Administration 11/2005